While there are many highly competitive matchups on the Week 17 NFL schedule, there are also games that appear lopsided on paper. Four of the Week 17 NFL spreads are at least 12.5 points at Caesars Sportsbook, including Patriots vs. Jaguars. Despite losing two straight and Mac Jones seemingly hitting the rookie wall, the Patriots are 15.5-point favorites in the NFL odds to dispose of the Jaguars, who have the league’s worst record at 2-13.
A win would all but secure a playoff spot for New England, while a loss would nearly lock up the first overall pick in the 2022 draft for Jacksonville. Thus, there are incentives for both teams for the game’s result to go the way oddsmakers believe it will. All of the Week 17 NFL lines are listed below and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 17 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up over $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 17 of the 2021 season on an incredible 134-96 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Top Week 17 NFL predictions
One of the model’s strongest Week 17 NFL picks is that the Cardinals (+5.5) cover the spread against the Cowboys. Dallas has won four straight, but all of those were against teams currently with losing records. Arizona’s three-game losing streak doesn’t inspire confidence, but the team fares much better on the road than at home. The Cards have won seven of eight away games, while Dallas has split its last four home contests.
With Kyler Murray, Chase Edmonds and a returning James Conner, Arizona has a multi-dimensional rushing attack that can exploit Dallas’ weakness. The Cowboys allow 4.5 yards per rush, which ranks among the bottom 10, and the model sees the three Cards having success on Sunday. Arizona should be able to stick with Dallas throughout and the model has the Cardinals (+5.5) staying within the spread in almost 60 percent of simulations.
Another one of its Week 17 NFL predictions: The Steelers (+3) cover against the Browns on Monday Night Football. This is an eliminator game as the winner will have just under a 25 percent chance of making the postseason, while the loser will be eliminated from playoff contention. Recent history favors Pittsburgh as since Ben Roethlisberger was drafted in 2004, the Steelers are 29-6-1 against the Browns straight up. The Steelers have also covered in their last four regular season meetings with the Browns.
Baker Mayfield’s play hasn’t given any indication that he’ll end that streak as he’s been dreadful over the last month. He’s had more touchdowns than turnovers just once over his last five games and the model predicts that stat will be once over his last six games following Monday Night Football. Pittsburgh is projected to win straight up as the underdog and to cover almost 60 percent of the time. The model also says you should back the Over (40.5) in that game as the teams are projected to combine for 41 points.
How to make Week 17 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 17 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.
So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,100 since its inception, and find out.
Week 17 NFL odds, spreads, lines
Sunday, Jan. 2
Featured Game | Indianapolis Colts vs. Las Vegas Raiders
Featured Game | Chicago Bears vs. New York Giants
Featured Game | New York Jets vs. Tampa Bay Buccaneers
Featured Game | Buffalo Bills vs. Atlanta Falcons
Eagles at Washington (+4, 46)
Featured Game | Washington Football Team vs. Philadelphia Eagles
Featured Game | Cincinnati Bengals vs. Kansas City Chiefs
Featured Game | New England Patriots vs. Jacksonville Jaguars
Featured Game | Tennessee Titans vs. Miami Dolphins
Featured Game | Baltimore Ravens vs. Los Angeles Rams
Featured Game | Los Angeles Chargers vs. Denver Broncos
Featured Game | San Francisco 49ers vs. Houston Texans
Cardinals at Cowboys (-5.5, 51.5)
Featured Game | Dallas Cowboys vs. Arizona Cardinals
Featured Game | New Orleans Saints vs. Carolina Panthers
Featured Game | Seattle Seahawks vs. Detroit Lions
Featured Game | Green Bay Packers vs. Minnesota Vikings
Monday, Jan. 3
Browns at Steelers (+3, 40.5)
Featured Game | Pittsburgh Steelers vs. Cleveland Browns